发给老马备查:3 A5 `; y/ p/ } F# `
滴水察海(69304838) 15:23:23# M }+ l4 B2 q, N7 L
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱" T* D7 ^4 H0 x
吉非替尼和S-1连用的依据- |# B5 Q x# q$ j# n
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.! e: E4 v, K8 D7 ~
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达& @5 p- o+ x3 W+ \0 q$ B& T9 ~
这样是不是推理出,耐药后,可以用S-1和培美了?5 }, b) A0 W0 i$ x+ \
结论:- l/ E% g" _4 C& H% w
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |